If you or someone you love has been prescribed daraxonrasib (Revolution Medicines' investigational RAS inhibitor, also known as RMC-6236), you have likely heard about its most common side effect: a skin rash. The good news is that the rash is usually manageable, rarely forces patients off treatment, and responds well to a thoughtful, gentle skincare routine. This guide explains what to expect and how to care for your skin day to day.

Understanding the daraxonrasib rash

Daraxonrasib works differently from traditional chemotherapy. By targeting the RAS pathway that drives many cancers, it tends to cause less of the severe fatigue and nausea seen with older treatments — but that same mechanism commonly affects the skin. In clinical trials, a skin rash was the most frequently reported side effect, occurring in roughly 86–90% of patients. The reassuring part: the large majority of cases are mild to moderate, and severe rash is far less common.

Where and when the rash shows up

The rash often begins on the face and can spread to the scalp, chest, and back. It typically resembles an acne-like (acneiform) rash and may feel inflamed, sore, dry, or tight, sometimes with flaking or peeling. It usually appears within the first weeks of treatment. Knowing where it tends to surface helps you get ahead of it with gentle, consistent care.

How care teams manage it

Because the daraxonrasib rash is predictable, oncologists and dermatologists usually manage it proactively rather than waiting for it to worsen. Two main tools are used:

Topical and supportive care

Care teams often recommend gentle cleansing, diligent moisturizing, sun protection, and prescription topical creams to calm the skin and protect its barrier. Many oncology programs partner with dermatology to keep patients comfortable and on treatment.

Dose modification

If the rash becomes severe or painful, an oncologist may temporarily pause ("hold") the medication or lower the daily dose until the skin recovers. Encouragingly, only about 1% of patients in trials stopped daraxonrasib because of treatment-related side effects — a sign the rash is generally well controlled.

Why gentle, barrier-supporting skincare matters

Skin under targeted-therapy stress is more fragile, drier, and more reactive than usual. The wrong products — anything with acids, exfoliants, strong fragrance, alcohol, or harsh "active" ingredients — can sting and make irritation worse. The goal is the opposite: clean gently, lock in moisture, and reinforce the skin barrier without irritation.

A simple 3-step Lindi Skin regimen

Lindi Skin was created with oncologists and dermatologists specifically for skin compromised by cancer treatment. The formulas deliberately leave out acids, exfoliants, heavy perfumes, and peeling agents, and instead use rich botanicals and antioxidants to soothe and hydrate. (A Northwestern University study found Lindi Skin helped soothe skin irritated by cancer treatment and improved patients' quality of life.) For skin coping with the daraxonrasib rash, three products work together as an easy daily routine.

Essential Chemo Skincare Collection — Body Lotion + Face Serum + Soothing Balm